Arizona Cardinals at San Francisco 49ers odds and lines

That Arizona Cardinals (4-12) complete the regular season away against the NFC West champion San Francisco 49ers (12-4) in Week 18. Kickoff is Sunday at 4:25 p.m. ET at Levi’s Stadium in Santa Clara (FOX). Below we look at Cardinals vs 49ers odds by Tipico Sportsbook; Check back for all of our NFL tips and predictions.

The Cardinals lost their sixth straight game on Sunday, losing 20-19 to the Atlanta Falcons on a last-second 21-yard field goal. They covered the 7-point spread as underdogs with fourth-string QB David Blough beginning.

The 49ers have won 9 straight games and recently needed overtime for a 37-34 win at the Las Vegas Raiders in Week 17. However, they failed to cover as a 10-point favorite and grabbed a streak of 6 straight covers.

See also: All odds and lines of week 18

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Cardinals at 49ers odds

Provided by Tipico Sportsbook; For a full list, visit the USA TODAY Sports Scores and Sports Betting Hub. The lines were last updated Tuesday at 12:08 AM ET.

  • Money line (ML): Cardinals +650 (bet $100 to win $650) | 49ers -1000 (bet $1,000 to win $100)
  • Against the Spread (ATS): Cardinals +14 (-104) | 49er -14 (-116)
  • Over/Under (O/U): 40.5 (O: -110 | B: -110)

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Betting statistics 2022

  • ML: Cardinals 4-12 | 49ers 12-4
  • ATS: Cardinals 8-8 | 49ers 10-6
  • O/U: Cardinals 8-8 | 49ers 8-8

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Cardinals vs. 49ers head to head

The 49ers won the first meeting of Week 11 in Mexico City 38-10 as 10-point favorites — the Cardinals were the designated home team. The 49ers have a slight 33-29 all-time lead, but the Cardinals have won 2 of the last 3.

That will be 49ers QB Brock Purdy’s 1. Career launch against the Cardinals.

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